Octanoic acid in alcohol-responsive essential tremor: A randomized controlled study
نویسندگان
چکیده
منابع مشابه
Dose-escalation study of octanoic acid in patients with essential tremor.
BACKGROUND Recently, 1-octanol has been shown to have efficacy in treating patients with essential tremor (ET). The primary metabolite of 1-octanol is octanoic acid (OA), which is now thought to be the active substance that mediates tremor suppression. Our aim was to describe the maximum tolerated dose (MTD) of oral OA in patients with ET and assess the pharmacokinetics (PK) and pharmacodynamic...
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A randomised double-blind placebo-controlled trial of phenylethylmalonamide, the major metabolite of primidone was performed in eight patients with essential tremor. Phenylethylmalonamide was given in a daily dose of 400 mg for one week and 800 mg for a second week. The compound had no statistically significant effect on the amplitude of tremor assessed by an accelerometric method, tests of per...
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Background Essential tremor (ET) is among the most common neurological diseases and it often runs in families. How knowledgeable ET patients and their families are about their disease has been the subject of surprisingly little scholarship. Methods To fill this gap in knowledge, we administered a comprehensive 32-item survey (i.e., questions about etiology, pathophysiology, symptoms and signs...
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The main interest in this case is that the patient's fits started only towards the end of a prolonged period of lactation, during which calcium losses would be expected to increase.3 We speculate that lactation was a major factor in inducing the convulsions since it may have reduced an already low plasma calcium concentration to epileptogenic levels. A further possibility is that she had a fami...
متن کاملUnawareness of head tremor in essential tremor: a study of three samples of essential tremor patients.
To broadly sample ET in different settings, we selected cases from three settings: a tertiaryreferral center (largest sample),5 a population-based study in Manhattan,6 and a brain repository.7 As expected, cases differed in several respects (Table). Using the same clinical questionnaire, each case was asked whether he/she sometimes has a head tremor. A 20 minute videotaped tremor examination wa...
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ژورنال
عنوان ژورنال: Neurology
سال: 2013
ISSN: 0028-3878,1526-632X
DOI: 10.1212/wnl.0b013e3182840c4f